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<title>CoA-disolfuro reduttasi</title>
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<wx:section level="1" title="CoA-disolfuro reduttasi" id="wxsec1"><h1 class="pagetitle" id="wx1">CoA-disolfuro reduttasi</h1>

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<p id="wx6"> Questa voce di <a href="/wit/Enzimi" title="Enzimi" wx:linktype="known" wx:pagename="Enzimi" wx:page_id="1740" id="wx7">enzimi</a> è solo un <a href="/wit/Aiuto:Abbozzo" title="Aiuto:Abbozzo" wx:linktype="known" wx:pagename="Aiuto:Abbozzo" id="wx8">abbozzo</a>: <b id="wx9"><a href="http://wit/wit/index.php?title=CoA-disolfuro_reduttasi&amp;action=edit" class="external text" wx:linktype="external" rel="nofollow" id="wx10">contribuisci</a></b> a migliorarla secondo le <a href="/wit/Aiuto:Manuale_di_stile" title="Aiuto:Manuale di stile" wx:linktype="known" wx:pagename="Aiuto:Manuale_di_stile" id="wx11">convenzioni di Wikipedia</a>.</p>
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<div style="-moz-border-radius-topleft:.9em; background:#C2C3FF; border:1px solid #88A; width:100%; text-align:center; margin-bottom:.5em;" id="wx13"><b id="wx14">CoA-disolfuro reduttasi</b></div>

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<div style="background:#E2F3EF; border-top:2px solid #C2C3FF" id="wx18"><b id="wx19">Altri nomi</b></div>

<p id="wx20">CoA-disolfuro reduttasi (NADH<small id="wx21"><sub id="wx22">2</sub></small>); NADH<small id="wx23"><sub id="wx24">2</sub></small>:CoA-disolfuro ossidoreduttasi; CoA:NAD<small id="wx25"><sup id="wx26">+</sup></small> ossidoreduttasi; CoADR; coenzyme A disolfuro reduttasi</p>

<div style="background:#E2F3EF; border-top:2px solid #C2C3FF" id="wx27"><b id="wx28">Banche dati</b></div>

<p id="wx29"><a href="http://brenda.bc.uni-koeln.de/php/result_flat.php4?ecno=1.8.1.14" class="external text" wx:linktype="external" rel="nofollow" id="wx30">BRENDA</a> <a href="http://www.expasy.ch/cgi-bin/nicezyme.pl?1.8.1.14" class="external text" wx:linktype="external" rel="nofollow" id="wx31">EXPASY</a> <a href="http://xpdb.nist.gov/enzyme_thermodynamics/enzyme_compose_query.pl?EC=1.8.1.14" class="external text" wx:linktype="external" rel="nofollow" id="wx32">GTD</a> <a href="http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.8.1.14" class="external text" wx:linktype="external" rel="nofollow" id="wx33">KEGG</a> <a href="http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes/GetPage.pl?ec_number=1.8.1.14" class="external text" wx:linktype="external" rel="nofollow" id="wx34">PDB</a></p>

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<p id="wx43">La <b id="wx44">CoA-disolfuro reduttasi</b> è un <a href="/wit/Enzima" title="Enzima" wx:linktype="known" wx:pagename="Enzima" wx:page_id="21081" id="wx45">enzima</a> appartenente alla classe delle <a href="/wit/Ossidoreduttasi" title="Ossidoreduttasi" wx:linktype="known" wx:pagename="Ossidoreduttasi" wx:page_id="416919" id="wx46">ossidoreduttasi</a>, che catalizza la seguente <a href="/wit/Reazione_chimica" title="Reazione chimica" wx:linktype="known" wx:pagename="Reazione_chimica" wx:page_id="51512" id="wx47">reazione</a>:</p>

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<dd id="wx49"><b id="wx50">2</b> <a href="/wit/CoA" title="CoA" wx:linktype="known" wx:pagename="CoA" wx:page_id="293244" id="wx51">CoA</a>
<p id="wx52">+ NAD(P)<small id="wx53"><sup id="wx54">+</sup></small> <wx:template id="wx_t3" pagename="Template:Unicode" page_id="87605"/><span class="Unicode" style="font-family: Code2000, TITUS Cyberbit Basic, Doulos SIL, Chrysanthi Unicode, Arial Unicode MS, Bitstream Cyberbit, Bitstream Vera, Gentium, GentiumAlt, Lucida Sans Unicode; font-family  :inherit;" id="wx55">⇄</span><wx:templateend start="wx_t3"/> CoA-<a href="/wit/Disolfuro" title="Disolfuro" wx:linktype="known" wx:pagename="Disolfuro" wx:page_id="1448085" id="wx56">disolfuro</a> + NAD(P)H + H<small id="wx57"><sup id="wx58">+</sup></small></p>
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<p id="wx59">L'enzima è una <a href="/wit/Flavoproteina" title="Flavoproteina" wx:linktype="known" wx:pagename="Flavoproteina" wx:page_id="1442560" id="wx60">flavoproteina</a> differente dalla <a href="/wit/Cistina_reduttasi" title="Cistina reduttasi" wx:linktype="known" wx:pagename="Cistina_reduttasi" wx:page_id="1540192" id="wx61">cistina reduttasi</a>, dalla <a href="/wit/Glutatione-disolfuro_reduttasi" title="Glutatione-disolfuro reduttasi" wx:linktype="known" wx:pagename="Glutatione-disolfuro_reduttasi" wx:page_id="1540193" id="wx62">glutatione-disolfuro reduttasi</a> o dalla <a href="/wit/Bis-gamma-glutamilcistina_reduttasi" title="Bis-gamma-glutamilcistina reduttasi" wx:linktype="known" wx:pagename="Bis-gamma-glutamilcistina_reduttasi" wx:page_id="1540200" id="wx63">bis-gamma-glutamilcistina reduttasi</a>. Mentre l'enzima presente in <i id="wx64"><a href="/wit/Staphylococcus_aureus" title="Staphylococcus aureus" wx:linktype="known" wx:pagename="Staphylococcus_aureus" wx:page_id="420655" id="wx65">Staphylococcus aureus</a></i> presenta una notevole preferenza per il <a href="/wit/NADPH" title="NADPH" wx:linktype="known" wx:pagename="NADPH" wx:page_id="783335" id="wx66">NADPH</a>, quello dell'<a href="/wit/Archeobatterio" class="new" title="Archeobatterio" wx:linktype="unknown" wx:pagename="Archeobatterio" id="wx67">archeobatterio</a> <i id="wx68"><a href="/wit/Pyrococcus_horikoshii" class="new" title="Pyrococcus horikoshii" wx:linktype="unknown" wx:pagename="Pyrococcus_horikoshii" id="wx69">Pyrococcus horikoshii</a></i> può usare efficientemente sia <a href="/wit/NADH" title="NADH" wx:linktype="known" wx:pagename="NADH" wx:page_id="520811" id="wx70">NADH</a> che NADPH.</p>

<a id="Bibliografia" name="Bibliografia"/>
<wx:section level="2" title="Bibliografia" id="wxsec2"><h2 id="wx71">Bibliografia</h2>

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<li id="wx73"><wx:template id="wx_t4" pagename="Template:Cita_pubblicazione" page_id="654720"/><cite style="font-style:normal" id="wx74">Harris, D.R., Ward, D.E., Feasel, J.M., Lancaster, K.M., Murphy, R.D., Mallet, T.C. and Crane, E.J., 3rd. (2005).  <i id="wx75">Discovery and characterization of a coenzyme A disulfide reductase from</i> Pyrococcus horikoshii<i id="wx76">. Implications for this disulfide metabolism of anaerobic hyperthermophiles</i> FEBS J. <b id="wx77">272</b>: 1189–1200. <a href="/wit/Entrez" title="Entrez" wx:linktype="known" wx:pagename="Entrez" wx:page_id="681159" id="wx78">Entrez PubMed</a> <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=15720393" class="external text" wx:linktype="external" rel="nofollow" id="wx79">15720393</a>.</cite><wx:templateend start="wx_t4"/>
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<li id="wx80"><wx:template id="wx_t5" pagename="Template:Cita_pubblicazione" page_id="654720"/><cite style="font-style:normal" id="wx81">Luba, J., Charrier, V. and Claiborne, A. (1999).  <i id="wx82">Coenzyme A-disulfide reductase from</i> Staphylococcus <i id="wx83">aureus'<b id="wx84">: evidence for asymmetric behavior on interaction with pyridine nucleotides</b></i> <b id="wx85">Biochemistry</b> 38<b id="wx86">: 2725–2737. <a href="/wit/Entrez" title="Entrez" wx:linktype="known" wx:pagename="Entrez" wx:page_id="681159" id="wx87">Entrez PubMed</a> <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=10052943" class="external text" wx:linktype="external" rel="nofollow" id="wx88">10052943</a>.</b><wx:templateend start="wx_t5"/></cite></li>

<li id="wx89"><wx:template id="wx_t6" pagename="Template:Cita_pubblicazione" page_id="654720"/><cite style="font-style:normal" id="wx90">delCardayré, S.B., Stock, K.P., Newton, G.L., Fahey, R.C. and Davies, J.E. (1998).  <i id="wx91">Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from</i> Staphylococcus <i id="wx92">aureus'<b id="wx93">. Purification and characterization of the native enzyme</b></i> <b id="wx94">J. Biol. Chem.</b> 273<b id="wx95">: 5744–5751. <a href="/wit/Entrez" title="Entrez" wx:linktype="known" wx:pagename="Entrez" wx:page_id="681159" id="wx96">Entrez PubMed</a> <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=9488707" class="external text" wx:linktype="external" rel="nofollow" id="wx97">9488707</a>.</b><wx:templateend start="wx_t6"/></cite></li>

<li id="wx98"><wx:template id="wx_t7" pagename="Template:Cita_pubblicazione" page_id="654720"/><cite style="font-style:normal" id="wx99">Setlow, B. and Setlow, P. (1977).  <i id="wx100">Levels of acetyl coenzyme A, reduced and oxidized coenzyme A, and coenzyme A in disulfide linkage to protein in dormant and germinated spores and growing and sporulating cells of</i> Bacillus megaterium <i id="wx101"/>J. Bacteriol. <b id="wx102">132</b>: 444–452. <a href="/wit/Entrez" title="Entrez" wx:linktype="known" wx:pagename="Entrez" wx:page_id="681159" id="wx103">Entrez PubMed</a> <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=410791" class="external text" wx:linktype="external" rel="nofollow" id="wx104">410791</a>.</cite><wx:templateend start="wx_t7"/>
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<a href="/wit/index.php?title=Speciale:Categories&amp;article=CoA-disolfuro_reduttasi" title="Speciale:Categories" wx:linktype="known" wx:pagename="Speciale:Categories" id="wx105">Categorie</a>: <span dir="ltr" id="wx106"><a href="/wit/Categoria:Stub_enzimi" title="Categoria:Stub enzimi" wx:linktype="known" wx:pagename="Categoria:Stub_enzimi" wx:page_id="747485" id="wx107">Stub enzimi</a></span> | <span dir="ltr" id="wx108"><a href="/wit/Categoria:EC_1.8.1" title="Categoria:EC 1.8.1" wx:linktype="known" wx:pagename="Categoria:EC_1.8.1" wx:page_id="1271495" id="wx109">EC 1.8.1</a></span></div>
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<p id="wx110">enzimi</p>
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<p id="wx111">CoA-disolfuro reduttasi</p>
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<p id="wx112">1.8.1.14</p>
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<p id="wx113">CoA:NAD(P)<small id="wx114"><sup id="wx115">+</sup></small> ossidoreduttasi</p>
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<p id="wx116">CoA-disolfuro reduttasi (NADH<small id="wx117"><sub id="wx118">2</sub></small>); NADH<small id="wx119"><sub id="wx120">2</sub></small>:CoA-disolfuro ossidoreduttasi; CoA:NAD<small id="wx121"><sup id="wx122">+</sup></small> ossidoreduttasi; CoADR; coenzyme A disolfuro reduttasi</p>
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<p id="wx123">⇄</p>
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<p id="wx124">Harris, D.R., Ward, D.E., Feasel, J.M., Lancaster, K.M., Murphy, R.D., Mallet, T.C. and Crane, E.J., 3rd.</p>
</wx:argument><wx:argument name="titolo">
<p id="wx125">Discovery and characterization of a coenzyme A disulfide reductase from <i id="wx126">Pyrococcus horikoshii</i>. Implications for this disulfide metabolism of anaerobic hyperthermophiles</p>
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<p id="wx127">FEBS J.</p>
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<p id="wx128">272</p>
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<p id="wx129">2005</p>
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<p id="wx147">J. Biol. Chem.</p>
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<p id="wx156">J. Bacteriol.</p>
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