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<wx:section level="1" title="Sindrome di Holt-Oram" id="wxsec1"><h1 class="pagetitle" id="wx1">Sindrome di Holt-Oram</h1>

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<p id="wx8">Le informazioni qui riportate hanno solo un fine illustrativo: non sono riferibili né a prescrizioni né a consigli medici - <b id="wx9"><a href="/wit/Wikipedia:Disclaimer_medico" title="Wikipedia:Disclaimer medico" wx:linktype="known" wx:pagename="Wikipedia:Disclaimer_medico" id="wx10">Leggi le avvertenze</a></b></p>
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<td style="padding: 0 5px 0 5px; font-size:95%; text-align:center" colspan="2" id="wx21"><b id="wx22"><a href="/wit/Malattie_rare" title="Malattie rare" wx:linktype="known" wx:pagename="Malattie_rare" wx:page_id="118385" id="wx23">Malattia rara</a></b> </td>
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<td style="padding: 0 5px 0 5px" id="wx28"><a href="/wit/Servizio_sanitario_nazionale" title="Servizio sanitario nazionale" wx:linktype="known" wx:pagename="Servizio_sanitario_nazionale" wx:page_id="788350" id="wx29">SSN italiano</a> </td>
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<p id="wx31">{{{RaraIT}}}</p>
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<td style="background:#ccccff; font-size:95%; border-top:1px solid #aaaaaa; border-bottom:1px solid #aaaaaa; padding:0 5px 0 5px; text-align:center" colspan="2" id="wx33"><i id="wx34">Classificazione e risorse esterne</i> </td>
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<td style="padding: 0 5px 0 5px" id="wx36"><a href="/wit/Classificazione_ICD" title="Classificazione ICD" wx:linktype="known" wx:pagename="Classificazione_ICD" wx:page_id="1271012" id="wx37">ICD</a>
<p id="wx38">-<a href="/wit/ICD-9" class="new" title="ICD-9" wx:linktype="unknown" wx:pagename="ICD-9" id="wx39">9</a>-CM</p>
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<p id="wx41">(<span style="font-weight:bolder; font-size:80%" id="wx42"><a href="/wit/Lingua_inglese" title="Lingua inglese" wx:linktype="known" wx:pagename="Lingua_inglese" wx:page_id="2523" id="wx43">EN</a></span>) <a href="http://www.icd9data.com/getICD9Code.ashx?icd9=xxx" class="external text" wx:linktype="external" rel="nofollow" id="wx44">xxx</a></p>
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<td style="padding: 0 5px 0 5px" id="wx46"><a href="/wit/Classificazione_ICD" title="Classificazione ICD" wx:linktype="known" wx:pagename="Classificazione_ICD" wx:page_id="1271012" id="wx47">ICD</a>
<p id="wx48">-<a href="/wit/ICD-10" title="ICD-10" wx:linktype="known" wx:pagename="ICD-10" wx:page_id="1253978" id="wx49">10</a></p>
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<td id="wx50">
<p id="wx51">(<span style="font-weight:bolder; font-size:80%" id="wx52"><a href="/wit/Lingua_inglese" title="Lingua inglese" wx:linktype="known" wx:pagename="Lingua_inglese" wx:page_id="2523" id="wx53">EN</a></span>) <a href="http://www.who.int/classifications/apps/icd/icd10online/?gq80.htm+q872" class="external text" wx:linktype="external" rel="nofollow" id="wx54">Q87.2</a></p>
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Per <b id="wx99">Sindrome di Holt-Oram</b> in campo medico, si intende una patologia autosomica dominante con vari difetti strutturali del <a href="/wit/Cuore" title="Cuore" wx:linktype="known" wx:pagename="Cuore" wx:page_id="766039" id="wx100">cuore</a>, tramite <a href="/wit/Cardiopatia_congenita" class="new" title="Cardiopatia congenita" wx:linktype="unknown" wx:pagename="Cardiopatia_congenita" id="wx101">cardiopatia congenita</a> e degli arti superiori. La gravità del difetto di sviluppo può variare di molto a seconda della persona coinvolta senza che esista un preciso schema.</p>

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<a id="Sintomatologia" name="Sintomatologia"/>
<wx:section level="2" title="Sintomatologia" id="wxsec2"><h2 id="wx102"><a href="/wit/Sintomatologia" title="Sintomatologia" wx:linktype="known" wx:pagename="Sintomatologia" wx:page_id="116125" id="wx103">Sintomatologia</a></h2>

<p id="wx104">Per quanto riguarda gli arti superiori possono interessare una o entrambe le <a href="/wit/Braccia" title="Braccia" wx:linktype="known" wx:pagename="Braccia" wx:page_id="736704" id="wx105">braccia</a>, coinvolgendo le creste embrionali radiali e si manifestano con <a href="/wit/Ipoplasia" title="Ipoplasia" wx:linktype="known" wx:pagename="Ipoplasia" wx:page_id="1736552" id="wx106">ipoplasia</a>, <a href="/wit/Aplasia" class="new" title="Aplasia" wx:linktype="unknown" wx:pagename="Aplasia" id="wx107">aplasia</a>, alterato sviluppo delle ossa radiali, ipotrofia delle emitenze tenar, <a href="/wit/Focomelia" title="Focomelia" wx:linktype="known" wx:pagename="Focomelia" wx:page_id="1535228" id="wx108">focomelia</a>. Per il cuore si manifesta in modo del tutto variabile, a volte non si manifesta neanche, senza riuscire a stilare una lista esatta, fra esse comunemente si ricorda la <a href="/wit/Bradicardia" title="Bradicardia" wx:linktype="known" wx:pagename="Bradicardia" wx:page_id="61172" id="wx109">bradicardia</a>.</p>

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<p id="wx114">Si è scoperto che la causa di tale sindrome è da imputare ad un <a href="/wit/Gene" title="Gene" wx:linktype="known" wx:pagename="Gene" wx:page_id="1723644" id="wx115">gene</a> denominato TBX5 situato al livello 12q24.1</p>

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</wx:section><wx:section level="2" title="Voci correlate" id="wxsec4"><h2 id="wx118">Voci correlate</h2>

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<li id="wx131"><wx:template id="wx_t3" pagename="Template:Cita_libro" page_id="462037"/><cite id="CITEREF" class="book" style="font-style:normal">Joseph C. Sengen. <i id="wx132">Concise Dictionary of Modern Medicine</i>. New York,  McGraw-Hill.  <a href="/wit/index.php?title=Speciale:Booksources&amp;isbn=9788838639173" class="internal" id="wx133">ISBN 978-88-386-3917-3</a></cite><wx:templateend start="wx_t3"/>
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<li id="wx134"><wx:template id="wx_t4" pagename="Template:Cita_libro" page_id="462037"/><cite id="CITEREF_1" class="book" style="font-style:normal">Harrison. <i id="wx135">Principi di Medicina Interna (il manuale - 16a edizione)</i>. New York - Milano,  McGraw-Hill, <a href="/wit/2006" title="2006" wx:linktype="known" wx:pagename="2006" wx:page_id="40247" id="wx136">2006</a>.   <a href="/wit/index.php?title=Speciale:Booksources&amp;isbn=8838624593" class="internal" id="wx137">ISBN 88-386-2459-3</a></cite><wx:templateend start="wx_t4"/>
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<li id="wx138"><wx:template id="wx_t5" pagename="Template:Cita_libro" page_id="462037"/><cite id="CITEREF_2" class="book" style="font-style:normal">Hurst. <i id="wx139">Il Cuore (il manuale - 11a edizione)</i>. Milano,  McGraw-Hill, <a href="/wit/2006" title="2006" wx:linktype="known" wx:pagename="2006" wx:page_id="40247" id="wx140">2006</a>.   <a href="/wit/index.php?title=Speciale:Booksources&amp;isbn=9788838623882" class="internal" id="wx141">ISBN 97-888-386-2388-2</a></cite><wx:templateend start="wx_t5"/>
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<li id="wx142"><wx:template id="wx_t6" pagename="Template:Cita_libro" page_id="462037"/><cite id="CITEREF_3" class="book" style="font-style:normal">Eugene Braunwald. <i id="wx143">Malattie del cuore (7a edizione)</i>. Milano,  Elsevier Masson, <a href="/wit/2007" title="2007" wx:linktype="known" wx:pagename="2007" wx:page_id="1221032" id="wx144">2007</a>.   <a href="/wit/index.php?title=Speciale:Booksources&amp;isbn=9788821429873" class="internal" id="wx145">ISBN 978-88-214-2987-3</a></cite><wx:templateend start="wx_t6"/>
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<li style="float:left; height:27px; line-height:25px; width:100%; margin:0; margin-top:.5em; margin-left:0; margin-right:0; padding:0; border:1px solid #CCF; background-color:#F0EEFF" title="Accedi alle voci di Wikipedia che parlano di medicina" id="wx148"><a href="/wit/Immagine:Stub_medicina.png" title="medicina" wx:linktype="image" wx:pagename="Immagine:Stub_medicina.png" wx:page_id="505006" id="wx149"><img src="/wit/Immagine:Stub_medicina.png" alt="medicina" width="25" height="25" id="wx150"/></a> <b id="wx151"><a href="/wit/Portale:medicina" class="new" title="Portale:medicina" wx:linktype="unknown" wx:pagename="Portale:medicina" id="wx152">Portale Medicina</a></b>
<p id="wx153">:  accedi alle voci di Wikipedia che parlano di medicina</p>
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<a href="/wit/index.php?title=Speciale:Categories&amp;article=Sindrome_di_Holt-Oram" title="Speciale:Categories" wx:linktype="known" wx:pagename="Speciale:Categories" id="wx154">Categoria</a>: <span dir="ltr" id="wx155"><a href="/wit/Categoria:Cardiologia" title="Categoria:Cardiologia" wx:linktype="known" wx:pagename="Categoria:Cardiologia" wx:page_id="75809" id="wx156">Cardiologia</a></span></div>
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Altre lingue: <a href="http://de.wikipedia.org/wiki/Holt-Oram-Syndrom" class="external" wx:linktype="interwiki" wx:pagename="de:Holt-Oram-Syndrom" id="wx157">Deutsch</a> | <a href="http://en.wikipedia.org/wiki/Holt-Oram_syndrome" class="external" wx:linktype="interwiki" wx:pagename="en:Holt-Oram_syndrome" id="wx158">English</a> | <a href="http://fr.wikipedia.org/wiki/Syndrome_de_Holt-Oram" class="external" wx:linktype="interwiki" wx:pagename="fr:Syndrome_de_Holt-Oram" id="wx159">Français</a> | <a href="http://pl.wikipedia.org/wiki/Zesp%C3%B3%C5%82_Holt-Orama" class="external" wx:linktype="interwiki" wx:pagename="pl:Zespół_Holt-Orama" id="wx160">Polski</a> | <a href="http://ru.wikipedia.org/wiki/%D0%A1%D0%B8%D0%BD%D0%B4%D1%80%D0%BE%D0%BC_%D0%A5%D0%BE%D0%BB%D1%82-%D0%9E%D1%80%D0%B0%D0%BC%D0%B0" class="external" wx:linktype="interwiki" wx:pagename="ru:Синдром_Холт-Орама" id="wx161">Русский</a></div>
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