<?xml version="1.0" encoding="UTF-8"?>
<html xmlns="http://www.w3.org/1999/xhtml" xmlns:wx="http://ilps.science.uva.nl/WikiXML/wx" xml:lang="nl" lang="nl">
<head>
<title>Propranolol</title>
<meta name="wx_namespace" content="0"/>
<meta name="wx_pagename" content="Propranolol"/>
<meta name="wx_page_id" content="505073"/>
</head>
<body>
<div id="wx_article">
<wx:section level="1" title="Propranolol" id="wxsec1"><h1 class="pagetitle" id="wx1">Propranolol</h1>

<wx:template id="wx_t1" pagename="Sjabloon:Geneesmiddel" page_id="1272958"/>
<table class="toccolours" style="float:right; width:190px; margin-left: 1em; margin-bottom: 1em; font-size: 85%;" id="wx2">
<tr style="text-align:center;" id="wx3">
<td style="background: lightblue;" colspan="3" id="wx4"><b id="wx5">Propranolol</b> </td>
</tr>

<tr style="text-align: center;" id="wx6">
<td style="background: white;" colspan="2" id="wx7">
<div class="wx_image" wx:align="center" id="wx8"><a href="/wnl/Afbeelding:Propranolol.png" title="" wx:linktype="image" wx:pagename="Afbeelding:Propranolol.png" id="wx9"><img src="/wnl/Afbeelding:Propranolol.png" alt="" width="200" id="wx10"/></a></div>
</td>
</tr>

<tr id="wx11">
<td colspan="3" id="wx12">
<center id="wx13">
<p id="wx14">1-(isopropylamino)-3-(naftaleen-1-yloxy)propan-2-ol</p>
</center>
</td>
</tr>

<tr id="wx15">
<td style="background: lightblue;" colspan="3" id="wx16">
<center id="wx17"><b id="wx18"><a href="/wnl/Farmacie" title="Farmacie" wx:linktype="known" wx:pagename="Farmacie" wx:page_id="22022" id="wx19">Farmaceutische gegevens</a></b></center>
</td>
</tr>

<tr id="wx20">
<td id="wx21"><a href="/wnl/Biologische_beschikbaarheid" title="Biologische beschikbaarheid" wx:linktype="known" wx:pagename="Biologische_beschikbaarheid" wx:page_id="267001" id="wx22">Biol. beschikbaarheid</a>
<p id="wx23">:</p>
</td>
<td id="wx24">
<p id="wx25">30–70% (oraal)</p>
</td>
</tr>

<tr id="wx26">
<td id="wx27"><a href="/wnl/Metabolisatie" title="Metabolisatie" wx:linktype="known" wx:pagename="Metabolisatie" wx:page_id="437554" id="wx28">Metabolisatie</a>
<p id="wx29">:</p>
</td>
<td id="wx30"><a href="/wnl/Lever" title="Lever" wx:linktype="known" wx:pagename="Lever" wx:page_id="7239" id="wx31">Hepatisch</a> </td>
</tr>

<tr id="wx32">
<td id="wx33"><a href="/wnl/Halfwaardetijd" title="Halfwaardetijd" wx:linktype="known" wx:pagename="Halfwaardetijd" wx:page_id="1297769" id="wx34">Halfwaardetijd</a>
<p id="wx35">:</p>
</td>
<td id="wx36">
<p id="wx37">3–4 uur</p>
</td>
</tr>

<tr id="wx38">
<td id="wx39"><a href="/wnl/Excretie" title="Excretie" wx:linktype="known" wx:pagename="Excretie" wx:page_id="198056" id="wx40">Uitscheiding</a>
<p id="wx41">:</p>
</td>
<td id="wx42"><a href="/wnl/Nier_%28biologie%29" title="Nier (biologie)" wx:linktype="known" wx:pagename="Nier_(biologie)" wx:page_id="14825" id="wx43">Renaal</a>
<p id="wx44">(&lt; 1%)</p>
</td>
</tr>

<tr id="wx45">
<td style="background: lightblue;" colspan="3" id="wx46">
<center id="wx47"><b id="wx48">Gebruik</b></center>
</td>
</tr>

<tr id="wx49">
<td id="wx50"><a href="/wnl/Geneesmiddelengroep" title="Geneesmiddelengroep" wx:linktype="known" wx:pagename="Geneesmiddelengroep" wx:page_id="759127" id="wx51">Geneesmiddelengroep</a>
<p id="wx52">:</p>
</td>
<td id="wx53">
<p id="wx54">Antihypertensiva</p>
</td>
</tr>

<tr id="wx55">
<td id="wx56"><a href="/wnl/Subklasse" title="Subklasse" wx:linktype="known" wx:pagename="Subklasse" wx:page_id="943492" id="wx57">Subklasse</a>
<p id="wx58">:</p>
</td>
<td id="wx59">
<p id="wx60">Bèta-blokkers</p>
</td>
</tr>

<tr id="wx61">
<td valign="top" id="wx62"><a href="/wnl/Merknaam" title="Merknaam" wx:linktype="known" wx:pagename="Merknaam" wx:page_id="84511" id="wx63">Merknamen</a>
<p id="wx64">:</p>
</td>
<td id="wx65">
<p id="wx66">Inderal (AstraZeneca), Propranolol EG (Eurogenerics), Propranolol Teva (Teva)</p>
</td>
</tr>

<tr id="wx67">
<td id="wx68"><a href="/wnl/Indicatie" title="Indicatie" wx:linktype="known" wx:pagename="Indicatie" wx:page_id="744819" id="wx69">Indicaties</a>
<p id="wx70">:</p>
</td>
<td id="wx71">
<p id="wx72">Hypertensie, angina pectoris, secundaire preventie na myocardinfarct, supraventriculaire ritmestoornissen, hyperthyreose, idiopathisch beven, sociale fobie, migraine, slokdarmvarices, glaucoom</p>
</td>
</tr>

<tr id="wx73">
<td id="wx74"><a href="/wnl/Doktersrecept" title="Doktersrecept" wx:linktype="known" wx:pagename="Doktersrecept" wx:page_id="360997" id="wx75">Voorschrift/recept</a>
<p id="wx76">:</p>
</td>
<td id="wx77">
<p id="wx78">Vereist</p>
</td>
</tr>

<tr id="wx79">
<td id="wx80"><a href="/wnl/Toediening" title="Toediening" wx:linktype="known" wx:pagename="Toediening" wx:page_id="664099" id="wx81">Toediening</a>
<p id="wx82">:</p>
</td>
<td id="wx83"><a href="/wnl/Oraal" title="Oraal" wx:linktype="known" wx:pagename="Oraal" wx:page_id="133605" id="wx84">Oraal</a>
<p id="wx85">, <a href="/wnl/Intraveneus" title="Intraveneus" wx:linktype="known" wx:pagename="Intraveneus" wx:page_id="209517" id="wx86">intraveneus</a></p>
</td>
</tr>

<tr id="wx87">
<td style="background: lightblue;" colspan="3" id="wx88">
<center id="wx89"><b id="wx90">Voorzorgen</b></center>
</td>
</tr>

<tr id="wx91">
<td id="wx92"><a href="/wnl/Zwangerschapscategorie" title="Zwangerschapscategorie" wx:linktype="known" wx:pagename="Zwangerschapscategorie" wx:page_id="300788" id="wx93">Zwangerschapscat.</a>
<p id="wx94">:</p>
</td>
<td id="wx95">
<p id="wx96">C (<a href="/wnl/Australi%C3%AB_%28land%29" title="Australië (land)" wx:linktype="known" wx:pagename="Australië_(land)" wx:page_id="26972" id="wx97">Aus</a>)<br id="wx98"/>
C (<a href="/wnl/Verenigde_Staten" title="Verenigde Staten" wx:linktype="known" wx:pagename="Verenigde_Staten" wx:page_id="1838" id="wx99">VS</a>)</p>
</td>
</tr>

<tr id="wx100">
<td style="background: lightblue;" colspan="3" id="wx101">
<center id="wx102"><b id="wx103">Databanken</b></center>
</td>
</tr>

<tr id="wx104">
<td id="wx105"><a href="/wnl/CAS_nummer" title="CAS nummer" wx:linktype="known" wx:pagename="CAS_nummer" wx:page_id="229037" id="wx106">CAS nummer</a>
<p id="wx107">:</p>
</td>
<td id="wx108"><a href="http://nlm.nih.gov/cgi/mesh/2008/MB_cgi?rn=1&amp;term=525-66-6" class="external text" wx:linktype="external" rel="nofollow" id="wx109">525-66-6</a> </td>
</tr>

<tr id="wx110">
<td id="wx111"><a href="/wnl/ATC_code" title="ATC code" wx:linktype="known" wx:pagename="ATC_code" wx:page_id="267376" id="wx112">ATC code</a>
<p id="wx113"> :</p>
</td>
<td id="wx114"><a href="http://www.whocc.no/atcddd/indexdatabase/index.php?query=C07AA05" class="external text" wx:linktype="external" rel="nofollow" id="wx115">C07AA05</a> </td>
</tr>

<tr id="wx116">
<td id="wx117"><a href="/wnl/PubChem" title="PubChem" wx:linktype="known" wx:pagename="PubChem" wx:page_id="437551" id="wx118">PubChem</a>
<p id="wx119">:</p>
</td>
<td id="wx120"><a href="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4946" class="external text" wx:linktype="external" rel="nofollow" id="wx121">4946</a> </td>
</tr>

<tr id="wx122">
<td id="wx123"><a href="/wnl/DrugBank" title="DrugBank" wx:linktype="known" wx:pagename="DrugBank" wx:page_id="437511" id="wx124">DrugBank</a>
<p id="wx125">:</p>
</td>
<td id="wx126"><a href="http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00194.txt" class="external text" wx:linktype="external" rel="nofollow" id="wx127">APRD00194</a> </td>
</tr>

<tr id="wx128">
<td style="background: lightblue;" colspan="3" id="wx129">
<center id="wx130"><b id="wx131"><a href="/wnl/Scheikunde" title="Scheikunde" wx:linktype="known" wx:pagename="Scheikunde" wx:page_id="1575" id="wx132">Chemische gegevens</a></b></center>
</td>
</tr>

<tr id="wx133">
<td id="wx134"><a href="/wnl/Chemische_formule" title="Chemische formule" wx:linktype="known" wx:pagename="Chemische_formule" wx:page_id="188396" id="wx135">Formule</a>
<p id="wx136">:</p>
</td>
<td id="wx137">
<p id="wx138">C<sub id="wx139">16</sub>H<sub id="wx140">21</sub>NO<sub id="wx141">2</sub></p>
</td>
</tr>

<tr id="wx142">
<td id="wx143"><a href="/wnl/Molecuulgewicht" title="Molecuulgewicht" wx:linktype="known" wx:pagename="Molecuulgewicht" wx:page_id="70191" id="wx144">Molecuulgewicht</a>
<p id="wx145">:</p>
</td>
<td id="wx146">
<p id="wx147">259,34 <a href="/wnl/Gram_%28eenheid%29" title="Gram (eenheid)" wx:linktype="known" wx:pagename="Gram_(eenheid)" wx:page_id="66475" id="wx148">g</a>/<a href="/wnl/Mol_%28eenheid%29" title="Mol (eenheid)" wx:linktype="known" wx:pagename="Mol_(eenheid)" wx:page_id="3566" id="wx149">mol</a></p>
</td>
</tr>

<tr id="wx150">
<td style="background: lightblue;" colspan="3" id="wx151">
<center id="wx152"><a href="/wnl/Afbeelding:Esculaap4.svg" title="" wx:linktype="image" wx:pagename="Afbeelding:Esculaap4.svg" id="wx153"><img src="/wnl/Afbeelding:Esculaap4.svg" alt="" width="18" id="wx154"/></a>
<p id="wx155"> <a href="/wnl/Portaal:Geneeskunde" class="new" title="Portaal:Geneeskunde" wx:linktype="unknown" wx:pagename="Portaal:Geneeskunde" id="wx156">Geneeskundeportaal</a></p>
</center>
</td>
</tr>
</table>

<wx:templateend start="wx_t1"/>
<p id="wx157"><b id="wx158">Propranolol</b> is een niet-selectieve <a href="/wnl/Betablokker" title="Betablokker" wx:linktype="known" wx:pagename="Betablokker" wx:page_id="825708" id="wx159">betablokker</a> die voornamelijk gebruikt wordt bij de behandeling van <a href="/wnl/Hypertensie" title="Hypertensie" wx:linktype="known" wx:pagename="Hypertensie" wx:page_id="425998" id="wx160">hypertensie</a> en is in de handel onder de merknaam <b id="wx161">Inderal</b>. Propranolol werd in 1950 ontwikkeld door <a href="/wnl/James_Black" title="James Black" wx:linktype="known" wx:pagename="James_Black" wx:page_id="976823" id="wx162">James Black</a> die daarvoor de <a href="/wnl/Nobelprijs_voor_de_Geneeskunde" title="Nobelprijs voor de Geneeskunde" wx:linktype="known" wx:pagename="Nobelprijs_voor_de_Geneeskunde" wx:page_id="116383" id="wx163">Nobelprijs voor de Geneeskunde</a> in <a href="/wnl/1988" title="1988" wx:linktype="known" wx:pagename="1988" wx:page_id="2115" id="wx164">1988</a> werd toegekend.</p>

<a id="Contra-indicaties" name="Contra-indicaties"/>
<wx:section level="2" title="Contra-indicaties" id="wxsec2"><h2 id="wx165">Contra-indicaties</h2>

<ul id="wx166">
<li id="wx167">
<p id="wx168">in geval van sterk vertraagde hartslag (<a href="/wnl/Bradycardie" title="Bradycardie" wx:linktype="known" wx:pagename="Bradycardie" wx:page_id="671593" id="wx169">bradycardie</a>)</p>
</li>

<li id="wx170"><a href="/wnl/Astma" title="Astma" wx:linktype="known" wx:pagename="Astma" wx:page_id="48315" id="wx171">astma</a></li>

<li id="wx172">
<p id="wx173">bij geleidingsstoornissen in het hart</p>
</li>

<li id="wx174">
<p id="wx175">bij metabole acidose (zuurstofophoping in het lichaam)</p>
</li>

<li id="wx176">
<p id="wx177">langdurig vasten</p>
</li>
</ul>
</wx:section></wx:section></div>
<div id="wx_categorylinks">
<a href="/wnl/index.php?title=Speciaal:Categories&amp;article=Propranolol" title="Speciaal:Categories" wx:linktype="known" wx:pagename="Speciaal:Categories" id="wx178">Categorieën</a>: <span dir="ltr" id="wx179"><a href="/wnl/Categorie:Antihypertensivum" title="Categorie:Antihypertensivum" wx:linktype="known" wx:pagename="Categorie:Antihypertensivum" wx:page_id="1176208" id="wx180">Antihypertensivum</a></span> | <span dir="ltr" id="wx181"><a href="/wnl/Categorie:Betablokker" title="Categorie:Betablokker" wx:linktype="known" wx:pagename="Categorie:Betablokker" wx:page_id="877352" id="wx182">Betablokker</a></span> | <span dir="ltr" id="wx183"><a href="/wnl/Categorie:Amine" title="Categorie:Amine" wx:linktype="known" wx:pagename="Categorie:Amine" wx:page_id="681245" id="wx184">Amine</a></span> | <span dir="ltr" id="wx185"><a href="/wnl/Categorie:Alcohol_%28stofklasse%29" title="Categorie:Alcohol (stofklasse)" wx:linktype="known" wx:pagename="Categorie:Alcohol_(stofklasse)" wx:page_id="1166527" id="wx186">Alcohol (stofklasse)</a></span> | <span dir="ltr" id="wx187"><a href="/wnl/Categorie:Naftaleenderivaat" title="Categorie:Naftaleenderivaat" wx:linktype="known" wx:pagename="Categorie:Naftaleenderivaat" wx:page_id="1219686" id="wx188">Naftaleenderivaat</a></span> | <span dir="ltr" id="wx189"><a href="/wnl/Categorie:Ether" title="Categorie:Ether" wx:linktype="known" wx:pagename="Categorie:Ether" wx:page_id="304406" id="wx190">Ether</a></span></div>
<div id="wx_languagelinks">
in andere talen: <a href="http://de.wikipedia.org/wiki/Propranolol" class="external" wx:linktype="interwiki" wx:pagename="de:Propranolol" id="wx191">Deutsch</a> | <a href="http://en.wikipedia.org/wiki/Propranolol" class="external" wx:linktype="interwiki" wx:pagename="en:Propranolol" id="wx192">English</a> | <a href="http://es.wikipedia.org/wiki/Propranolol" class="external" wx:linktype="interwiki" wx:pagename="es:Propranolol" id="wx193">Español</a> | <a href="http://fr.wikipedia.org/wiki/Propranolol" class="external" wx:linktype="interwiki" wx:pagename="fr:Propranolol" id="wx194">Français</a> | <a href="http://hr.wikipedia.org/wiki/Propranolol" class="external" wx:linktype="interwiki" wx:pagename="hr:Propranolol" id="wx195">Hrvatski</a> | <a href="http://it.wikipedia.org/wiki/Propranololo" class="external" wx:linktype="interwiki" wx:pagename="it:Propranololo" id="wx196">Italiano</a> | <a href="http://ja.wikipedia.org/wiki/%E3%83%97%E3%83%AD%E3%83%97%E3%83%A9%E3%83%8E%E3%83%AD%E3%83%BC%E3%83%AB" class="external" wx:linktype="interwiki" wx:pagename="ja:プロプラノロール" id="wx197">日本語</a> | <a href="http://pl.wikipedia.org/wiki/Propranolol" class="external" wx:linktype="interwiki" wx:pagename="pl:Propranolol" id="wx198">Polski</a> | <a href="http://pt.wikipedia.org/wiki/Propranolol" class="external" wx:linktype="interwiki" wx:pagename="pt:Propranolol" id="wx199">Português</a> | <a href="http://ru.wikipedia.org/wiki/%D0%9F%D1%80%D0%BE%D0%BF%D1%80%D0%B0%D0%BD%D0%BE%D0%BB%D0%BE%D0%BB" class="external" wx:linktype="interwiki" wx:pagename="ru:Пропранолол" id="wx200">Русский</a> | <a href="http://th.wikipedia.org/wiki/%E0%B9%82%E0%B8%9E%E0%B8%A3%E0%B8%9E%E0%B8%B2%E0%B9%82%E0%B8%99%E0%B8%A5%E0%B8%AD%E0%B8%A5" class="external" wx:linktype="interwiki" wx:pagename="th:โพรพาโนลอล" id="wx201">ไทย</a></div>
</body>
<wx:templatearguments for="wx_t1"><wx:argument name="naam">
<p id="wx202">Propranolol</p>
</wx:argument><wx:argument name="afbeelding">
<p id="wx203">Propranolol.png</p>
</wx:argument><wx:argument name="onderschrift"/><wx:argument name="width">
<p id="wx204">200px</p>
</wx:argument><wx:argument name="IUPAC_naam">
<p id="wx205">1-(isopropylamino)-3-(naftaleen-1-yloxy)propan-2-ol</p>
</wx:argument><wx:argument name="beschikbaarheid">
<p id="wx206">30–70% (oraal)</p>
</wx:argument><wx:argument name="metabolisatie">
<a href="/wnl/Lever" title="Lever" wx:linktype="known" wx:pagename="Lever" wx:page_id="7239" id="wx207">Hepatisch</a>
</wx:argument><wx:argument name="halfwaardetijd">
<p id="wx208">3–4 uur</p>
</wx:argument><wx:argument name="excretie">
<a href="/wnl/Nier_%28biologie%29" title="Nier (biologie)" wx:linktype="known" wx:pagename="Nier_(biologie)" wx:page_id="14825" id="wx209">Renaal</a>
<p id="wx210">(&lt; 1%)</p>
</wx:argument><wx:argument name="groep">
<p id="wx211">Antihypertensiva</p>
</wx:argument><wx:argument name="subklasse">
<p id="wx212">Bèta-blokkers</p>
</wx:argument><wx:argument name="merknamen">
<p id="wx213">Inderal (AstraZeneca), Propranolol EG (Eurogenerics), Propranolol Teva (Teva)</p>
</wx:argument><wx:argument name="indicaties">
<p id="wx214">Hypertensie, angina pectoris, secundaire preventie na myocardinfarct, supraventriculaire ritmestoornissen, hyperthyreose, idiopathisch beven, sociale fobie, migraine, slokdarmvarices, glaucoom</p>
</wx:argument><wx:argument name="voorschrift">
<p id="wx215">Vereist</p>
</wx:argument><wx:argument name="toediening">
<a href="/wnl/Oraal" title="Oraal" wx:linktype="known" wx:pagename="Oraal" wx:page_id="133605" id="wx216">Oraal</a>
<p id="wx217">, <a href="/wnl/Intraveneus" title="Intraveneus" wx:linktype="known" wx:pagename="Intraveneus" wx:page_id="209517" id="wx218">intraveneus</a></p>
</wx:argument><wx:argument name="dosering"/><wx:argument name="zwangerschap">
<p id="wx219">C (<a href="/wnl/Australi%C3%AB_%28land%29" title="Australië (land)" wx:linktype="known" wx:pagename="Australië_(land)" wx:page_id="26972" id="wx220">Aus</a>)<br id="wx221"/>
C (<a href="/wnl/Verenigde_Staten" title="Verenigde Staten" wx:linktype="known" wx:pagename="Verenigde_Staten" wx:page_id="1838" id="wx222">VS</a>)</p>
</wx:argument><wx:argument name="lactatie"/><wx:argument name="rijvaardigheid"/><wx:argument name="alcohol"/><wx:argument name="voeding"/><wx:argument name="overdosis"/><wx:argument name="CAS_nummer">
<p id="wx223">525-66-6</p>
</wx:argument><wx:argument name="ATC_prefix">
<p id="wx224">C07</p>
</wx:argument><wx:argument name="ATC_suffix">
<p id="wx225">AA05</p>
</wx:argument><wx:argument name="PubChem">
<p id="wx226">4946</p>
</wx:argument><wx:argument name="DrugBank">
<p id="wx227">APRD00194</p>
</wx:argument><wx:argument name="repertorium"/><wx:argument name="chemische_formule">
<p id="wx228">C<sub id="wx229">16</sub>H<sub id="wx230">21</sub>NO<sub id="wx231">2</sub></p>
</wx:argument><wx:argument name="moleculair_gewicht">
<p id="wx232">259,34</p>
</wx:argument><wx:argument name="smeltpunt"/><wx:argument name="kleur"/><wx:argument name="oplosbaarheid"/><wx:argument name="dichtheid"/><wx:argument name="aggregatietoestand"/></wx:templatearguments>
</html>
